- Title
- Systemic inflammation in older adults with asthma-COPD overlap syndrome
- Creator
- Fu, Juan-Juan; McDonald, Vanessa M.; Gibson, Peter G.; Simpson, Jodie L.
- Relation
- NHMRC
- Relation
- Allergy, Asthma and Immunology Research Vol. 6, Issue 4, p. 316-324
- Publisher Link
- http://dx.doi.org/10.4168/aair.2014.6.4.316
- Publisher
- Korean Academy of Asthma, Allergy and Clinical Immunology
- Resource Type
- journal article
- Date
- 2014
- Description
- Purpose: The role of systemic inflammation on asthma-COPD overlap syndrome is unknown. This study aimed to examine systemic inflammation in asthma-COPD overlap syndrome, and to identify associations between clinical characteristics and inflammatory mediators in asthma-COPD overlap syndrome. Methods: In 108 adults older than 55 years comprising healthy controls (n=29), asthma (n=16), COPD (n=21) and asthma-COPD overlap syndrome (n=42), serum high sensitivity C-reactive protein and Interleukin 6 (IL-6) were assayed. Spirometry, induced sputum, quality of life, comorbidities and medications were assessed, and their associations with asthma-COPD overlap syndrome were analyzed using logistic regression. Associations between systemic inflammatory mediators and clinical characteristics were tested in multivariate linear regression models. Results: Patients with asthma-COPD overlap syndrome had significantly elevated IL-6 levels compared with healthy controls and asthmatics. Age, comorbidity index and IL-6 level were independently associated with asthma-COPD overlap syndrome. FEV1% predicted was inversely associated with IL-6 level, and cardiovascular disease was associated with an increased IL-6 level. Systemic markers were not associated with airway inflammation. Conclusions: Systemic inflammation is commonly present in asthma-COPD overlap syndrome, and asthma-COPD overlap syndrome resembled COPD in terms of systemic inflammation. IL-6 is a pivotal inflammatory mediator that may be involved in airflow obstruction and cardiovascular disease and may be an independent treatment target.
- Subject
- ageing; C-reactive protein; interleukin-6; asthma; obstructive airway disease; comorbidity
- Identifier
- http://hdl.handle.net/1959.13/1304867
- Identifier
- uon:20946
- Identifier
- ISSN:2092-7355
- Language
- eng
- Full Text
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